Submit Manuscript  

Article Details


Isolation, Characterization, and Docking Studies of (Z)-Isopropyl 7-((1R, 2R, 3R, 5S)- 2-((1E, 3Z)-3-Fluoro-4-Phenoxybuta-1, 3-Dienyl)-3,5-Dihydroxycyclopentyl) Hept-5- Enoate, an Impurity of Tafluprost

Author(s):

Rama Mohana Reddy Jaggavarapu, Venkatanarayana Muvvala*, Venkata Reddy.G and Ravi Kumar Cheedarala*   Pages 1 - 6 ( 6 )

Abstract:


Introduction: The origin, isolation, and characterization of (Z)-isopropyl 7-((1R, 2R, 3R, 5S)-2-((1E, 3Z)-3-fluoro-4-phenoxybuta-1, 3-dienyl)-3, 5-dihydroxycyclopentyl) hept-5-enoate, an impurity found in the preparation of an anti-glaucoma agent-Tafluprost has been described in this study.

Materials and Methods: Further, an enantiospecific synthesis of (Z)-isopropyl 7-((1R, 2R, 3R, 5S)-2-((1E, 3Z)- 3-fluoro-4-phenoxybuta-1, 3-dienyl)-3, 5-dihydroxycyclopentyl) hept-5-enoate has been revealed using deoxofluorination as a key transformation of the strategy.

Results and Discussions: Moreover, the impurity showing anti-glaucoma properties in docking studies with respect to bimatoprost has been described.

Conclusion: The extention of our work towards docking studies and the present impurity molecule showed almost the same biological activity with respect to Tafluprost.

Keywords:

Glaucoma, (Z)-isopropyl 7-((1R, 2R, 3R, 5S)-2-((1E, 3Z)-3-fluoro-4-phenoxybuta-1, 3-dienyl (-3, 5-dihydroxycyclopentyl) hept- 5-enoate, prostaglandins, tafluprost, docking studies.

Affiliation:

Department of Chemistry, Gitam School of Science, GITAM (Deemed to be University), Hyderabad, Telangana-502329, Department of Chemistry, Gitam School of Science, GITAM (Deemed to be University), Hyderabad, Telangana-502329, MSN Laboratories Pvt Ltd, Hyderabad, Department of Chemistry, Pohang University of Science and Technology (POSTECH), SAN31, Hyoja-dong



Read Full-Text article