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Multi-Component One-Pot Assisted Synthesis, Anti-bacterial Capabilities, and Scanning Electron Microscopy of Novel Corticosteroid Thiopyran

[ Vol. 18 , Issue. 4 ]

Author(s):

Sultanat*, Anam Ansari, Mohd Qamar, Shafiullah, Sartaj Tabassum and Firoz A. Ansari   Pages 411 - 417 ( 7 )

Abstract:


Background: Corticosteroids are an important group of polycyclic compounds having a wide range of pharmacological and physiological properties. Thiopyran derivatives are important building blocks of many biologically active compounds.

Objective: Keeping in mind the wide range of applications of corticosteroids and thiopyran, herein we intend to develop a simple and efficient strategy to synthesize steroidal thiopyran derivatives starting with different commercially available corticosteroids and study their biological properties.

Materials and Methods: To achieve our aim, we employed a one-pot multi-component synthesis of steroidal thiopyran derivatives by the reaction of corticosteroids, malononitrile, and carbon disulphide in the presence of triethylamine as a catalyst.

Results and Discussion: An array of novel thiopyran compounds was obtained with the highest product yield using Et3N. Scanning electron microscopy analysis manifested agglomeration pertaining to brick-shaped crystals of corticosteroid thiopyran. Synthesized compounds were also found to be active as anti-bacterial agents.

Conclusion: We describe a facile one-pot multi-component synthesis of corticosteroid thiopyran derivatives, which are found to possess anti-bacterial activity. Excellent yields of the products, simple work-up, easily available starting materials, and non-chromatographic purification are some of the main advantages of this protocol.

Keywords:

Corticosteroid, thiopyran, anti-bacterial, malononitrile, carbon disulphide, Et3N.

Affiliation:

Department of Chemistry, Aligarh Muslim University, Aligarh, (UP), 202002, Department of Chemistry, Aligarh Muslim University, Aligarh, (UP), 202002, Department of Chemistry, Aligarh Muslim University, Aligarh, (UP), 202002, Department of Chemistry, Aligarh Muslim University, Aligarh, (UP), 202002, Department of Chemistry, Aligarh Muslim University, Aligarh, (UP), 202002, Biofilm Research Lab, Department of Agriculture Microbiology, AMU, Aligarh (UP), 202002

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