Submit Manuscript  

Article Details


Multi-Component One-Pot Assisted Synthesis, Anti-bacterial Capabilities, and Scanning Electron Microscopy of Novel Corticosteroid Thiopyran

Author(s):

Sultanat*, Anam Ansari, Mohd Qamar, Shafiullah, Sartaj Tabassum and Firoz A. Ansari   Pages 1 - 7 ( 7 )

Abstract:


Background: Corticosteroids are important group of polycyclic compounds having a wide range of pharmacological and physiological properties. Thiopyran derivatives are important building blocks of many biologically active compounds.

Objective: Keeping in mind the wide range of application of corticosteroid and thiopyran, herein we intend to develop a simple and efficient strategy to synthesize steroidal thiopyran derivatives starting with different commercially available corticosteroid and study their biological property.

Materials and Methods: To achieve our aim, we employed a one-pot multicomponent synthesis of steroidal thiopyran derivatives by the reaction of corticosteriods, malononitrile and carbon disulphide in presence of triethyl amine as a catalyst.

Results and Discussion: An array of novel thiopyran compounds were obtained with the highest product yield using Et3N. Scanning electron microscopy analysis manifested agglomeration pertaining to brick - shaped crystals of corticosteroid thiopyran. Synthesized compound were also found to be active as antibacterial agents.

Conclusion: We describe a facile one-pot multicomponent synthesis of corticosteroid thiopyran derivatives which are found to possess antibacterial activity. Excellent yields of the products, simple work-up, easily available starting materials and non-chromatographic purification are some main advantages of this protocol.

Keywords:

Corticosteroid, thiopyran, anti-bacterial, malononitrile, carbon disulphide, Et3NCorticosteroid, thiopyran, anti-bacterial, malononitrile, carbon disulphide, Et3N

Affiliation:

Department of Chemistry, Aligarh Muslim University, Aligarh, (UP), 202002, Department of Chemistry, Aligarh Muslim University, Aligarh, (UP), 202002, Department of Chemistry, Aligarh Muslim University, Aligarh, (UP), 202002, Department of Chemistry, Aligarh Muslim University, Aligarh, (UP), 202002, Department of Chemistry, Aligarh Muslim University, Aligarh, (UP), 202002, Biofilm Research lab, Department of Agriculture Microbiology, AMU, Aligarh(UP), 202002



Read Full-Text article