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Iso-octenidine: Promising Octenidine Analogue with Improved Solubility

[ Vol. 18 , Issue. 5 ]

Author(s):

Igor K. Yakuschenko, Nataliya N. Pozdeeva, Viktoriya A. Mumyatova, Alexey A. Terentiev and Svyatoslav Ya. Gadomsky*   Pages 443 - 445 ( 3 )

Abstract:


Iso-octenidine, an isomer of octenidine dihydrochloride, was synthesized and studied for the first time. Iso-octenidine was demonstrated to be 3-fold more soluble in water in comparison to original octenidine, and both substances had remarkably similar antibacterial activity (tested on Escherichia Coli and Micrococcus luteus).

Keywords:

Octenidine dihydrochloride, bispyridinium salts, alkylation reaction, organic synthesis, solubility, antibacterial activity.

Affiliation:

Institute of Problems of Chemical Physics of the Russian Academy of Sciences, 142432 Chernogolovka, Moscow Region, Institute of Problems of Chemical Physics of the Russian Academy of Sciences, 142432 Chernogolovka, Moscow Region, Institute of Problems of Chemical Physics of the Russian Academy of Sciences, 142432 Chernogolovka, Moscow Region, Institute of Problems of Chemical Physics of the Russian Academy of Sciences, 142432 Chernogolovka, Moscow Region, Institute of Problems of Chemical Physics of the Russian Academy of Sciences, 142432 Chernogolovka, Moscow Region

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