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Facile Synthetic Protocols for the Preparation of New Impurities in Pemetrexed Disodium Heptahydrate as an Anti-Cancer Drug

Author(s):

Rama Mohana Reddy Jaggavarapu, Venkatanarayana Muvvala*, Venkatareddy Ghojala, H. Sharath Babu and Ravi Kumar Cheedarala*   Pages 1 - 8 ( 8 )

Abstract:


A facile synthetic protocol was employed to prepare process-related impurities associated with the synthesis of pemetrexed disodium heptahydrate, Alimta. The research work is described for the development of the novel synthetic methods and their structure elucidation of Pemetrexed glutamide, N-methyl pemetrexed, and N-methyl pemetrexed glutamide impurities. The listed impurities were deduced through spectral analysis, such as 1H-NMR, 13CNMR, and HRMS. The target compounds can be used as the reference substances for quality control.

Keywords:

Pemetrexed disodium, pemetrexed glutamide impurity, multi-targeted antifolate, N-methyl pemetrexed glutamide, L-Glutamic acid, alimta.

Affiliation:

Department of Chemistry, Gitam School of Science, GITAM (Deemed to be University), Hyderabad, Telangana-502329, Department of Chemistry, Gitam School of Science, GITAM (Deemed to be University), Hyderabad, Telangana-502329, MSN Laboratories Pvt. Ltd. Sy. No. 50, Kardanur (V), Patancheru(M), Sangareddy Dist., Telangana State, Department of Chemistry, Gitam School of Science, GITAM (Deemed to be University), Hyderabad, Telangana-502329,, Department of Chemistry, Pohang University of Science and Technology (POSTECH), San 31 Hyojadong, Pohang, Kyeongbuk 790-784



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