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Chemical Behavior of Cysteine in Organic Synthesis


Mahdieh Darroudi* and Ghodsi Mohammadi Ziarani*  


Introduction: Cysteine is a versatile amino acid for selective chemical modification of proteins with both chemical and biological innovations, which plays a key role in different organic reactions.

Materials and Methods: Chemical modification of proteins is a rapidly expanding area in chemical biology. Selective installation of biochemical probes has led to a better understanding of natural protein modification and macromolecular function. In other cases, such as chemical alterations, the protein function has entirely changed.This review paper considers the organic reaction of cysteine, concerning reactivity of this α-amino acid containing sulfur and several methodologies are also discussed. Herein, we focused on the reaction of cysteine and its application in organic synthesis, which includes addition, condensation, substitution, condensation, oxidation and ring-opening reactions.

Results and Discussion: Hence monitoring of cysteine is pivotal through the preparation of some fluorescent probe which can detect cysteine in high sensitivity. Also, a bibliometric analysis was carried out using Web of Science and Scopus databases that demonstrated significant contributions being observed in organic synthesis. Analysis of keywords revealed that research hotspots were cysteine, sensor, unclassified drug and amino acid. The topographical distribution maps showed the pattern of collaboration with the strongest links which have long work together along with high coverage of active researchers.

Conclusion: Therefore, it seems that future research focuses on using cysteine amino acid in various fields as natural products and organic reactions. This focus Review highlights the enduring utility of cysteine in protein modification and sensor preparation with a special focus on recent innovations in chemistry and biology associated with such modifications.


Cysteine, organic synthesis, substitution, addition, condensation, bibliometric analysis


Department of Chemistry, Faculty of Physic and Chemistry, Alzahra University, Tehran, Department of Chemistry, Faculty of Physic and Chemistry, Alzahra University, Tehran

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