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Strategies for the Synthesis of Mono- and Bis-Thionaphthoquinones

Author(s):

Vitor F. Ferreira*, Alcione S. de Carvalho and David R. da Rocha   Pages 1 - 12 ( 12 )

Abstract:


The subclass of compounds that have the nucleus 1,4-naphthoquinone is the most diverse of the class of quinones, which have a large number of substances and several that have useful applications ranging from medicinal chemistry to application in materials with special properties. The introduction of one or two substituents with the sulfur heteroatom in the naphthoquinone nucleus generates products containing alkyl and aryl groups that amplify certain biological properties against bacteria, viruses and fungi. There are several methods of preparing these compounds, mainly from low molecular weight naphthoquinones with two electrophilic sites capable of reacting with sulfides generating diversity and new classes of compounds, including new sulfur heterocycles and sulfur heterocycles fused with naphthoquinones. These compounds have been shown to be bioactive against several biological targets. This review will describe the methods of their synthesis and, when applicable, their biological activities.

Keywords:

1, 4-naphthoquinone, thionaphthoquinone, bis-thionaphthoquinone, sulfur-heterocycles, synthesis, medicinal chemistry

Affiliation:

Universidade Federal Fluminense, Faculdade de Farmácia, Departamento de Tecnologia Farmacêutica, Rua Doutor Mário Viana, 523, Santa Rosa, 24241-000, Niterói-RJ, Universidade Federal Fluminense, Departamento de Química Orgânica, Programa de Pós-Graduação em Química, Outeiro de São João Batista, s/n, Centro 24020-141 Niterói-RJ, Universidade Federal Fluminense, Departamento de Química Orgânica, Programa de Pós-Graduação em Química, Outeiro de São João Batista, s/n, Centro 24020-141 Niterói-RJ



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