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Recent Advances in Synthesis and Reactions of β-Amino-α ,β -Enones (Enaminones)

[ Vol. 18 , Issue. 7 ]


Thoraya Farghaly*, Alaa M. Abo Alnaja and Mohamed R. Shaaban*   Pages 639 - 684 ( 46 )


β-Amino-α,β-enones or β-enamino carbonyl compounds are versatile synthons intermediates for the construction of various bio-active heterocyclic compounds and have been established as multipurpose synthetic precursors in organic syntheses and in pharmaceutical developments. In this work, we will discuss the different synthetic routes to obtain β−amino−α,β-enones or β-enamino carbonyl compounds, their reactions, and their utility in the construction of organic frameworks and heterocyclic ring systems. Structurally, β- amino-α,β-enones are attractive intermediates that syndicate the ambident behaviours of nucleophilicity and electrophilicity of enones at the same time. β-amino-α,β-enones have been known as acceptors in both 1,2- and 1,4- additions that make them good intermediate compounds for annulation to different heterocycles.


Enaminones, nitrogen nucleophiles, heterocycles, synthesis, β-enamino, β-amino-α, β-enones.


Department of Chemistry, Faculty of Science, Cairo University, Giza 12613, Department of Chemistry, Faculty of Applied Science, Umm Al-Qura University, Makkah Almukaramah, Department of Chemistry, Faculty of Science, Cairo University, Giza 12613

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