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Recent Opportunities and Challenges in Selective C-H Functionalization of Methyl Azaarenes: a Highlight from 2010 to 2020 Literatures

Author(s):

Fahimeh Abedinifar, Mohammad Mahdavi*, Mehdi Asadi , Haleh Hamedifar , Samira Ansari and Bagher Larijani  

Abstract:


Azaarenes are unique scaffolds frequently found in pharmaceuticals. Herein, we have summarized the recent synthetic available methods in C–H functionalization of methylazaarenes from 2010 to 2020. Multiple approaches involving halogenation and alkylation via different methods, such as alkenylation, oxidative functionalization, and cyclization of the methylazaarenes will be discussed in this review.

Keywords:

Azaarenes, Pharmaceutical, C–H functionalization, Alkenylation, Oxidative, cyclization

Affiliation:

Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran 14176, Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran 14176, Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran 14176, CinnaGen Medical Biotechnology Research Center, Alborz University of Medical Sciences, Karaj, CinnaGen Medical Biotechnology Research Center, Alborz University of Medical Sciences, Karaj, Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran 14176



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