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Asymmetric Organocatalytic Syntheses of Bioactive Compounds

Author(s):

Estibaliz Sansinenea and Aurelio Ortiz*   Pages 1 - 18 ( 18 )

Abstract:


Background: The total syntheses of complex natural products have evolved to include new methodologies to save time, simplifying the form to achieve these natural compounds.

Objective: In this review, we have described the asymmetric synthesis of different natural products and biologically active compounds of the last ten years until the current day.

Results: An asymmetric organocatalytic reaction is a key to generate stereoselectively the main structure with the required stereochemistry.

Conclusion: Even more remarkable, the organocatalytic cascade reactions, which are carried out with high stereoselectivity, as well as a possible approximation of the organocatalysts activation with sub-strates are also described.

Keywords:

Organocatalysis, organocatalytic process, organocatalytic cascade reactions, asymmetric synthesis, natural products, stereoselec-tivity, catalyst.

Affiliation:

Facultad de Ciencias Químicas, Benemérita Universidad Autónoma de Puebla, Puebla, Facultad de Ciencias Químicas, Benemérita Universidad Autónoma de Puebla, Puebla



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