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Strategies in Synthetic Radical Organic Chemistry. Recent Advances on Cyclization and SRN1 Reactions

[ Vol. 3 , Issue. 2 ]


Roberto A. Rossi and Alicia B. Penenory   Pages 121 - 158 ( 38 )


Radical ring closure reactions by intramolecular addition of a radical to a tethered double bond afford a new cyclized radical intermediate that can be reduced, or further react with different reagents to yield substituted-cyclic compounds. The applications of SRN1 reactions are broad in scope, encompassing the utilization of poorly reactive substrates. We undertake a compilation to cover recent literature of these reactions and their synthetic applications.


Ring closure, reduction, SRN1, radicals, radical anions, electron transfer


INFIQC, Departamentode Quimica Organica, Facultad de Ciencias Quimicas, UniversidadNacional de Cordoba, 5000 Cordoba, Argentina.

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