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Preparation and Enantiomeric Excess Determination of Optically Active BINOL and BINOL Derivatives

[ Vol. 3 , Issue. 2 ]

Author(s):

Brian E. Love   Pages 169 - 185 ( 17 )

Abstract:


Methods of preparing 1,1-bi-2-naphthol (BINOL) in optically active form, are reviewed. Preparation of this compound and its derivatives through both resolution and asymmetric synthesis, are discussed. Methods of determining the enantiomeric excess of samples of optically active BINOL, both through chromatographic and spectroscopic means, are also reviewed.

Keywords:

BINOL, asymmetric synthesis, resolution, enantiomeric excess

Affiliation:

Department of Chemistry,East Carolina University, Greenville, NC 27858, USA.



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