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Synthesis of 2,3-Didehydro-2,3-dideoxynucleosides via Nucleoside Route.

[ Vol. 3 , Issue. 3 ]

Author(s):

Christophe Len and Denis Postel   Pages 261 - 281 ( 21 )

Abstract:


2,3-Didehydro- and 2,3-dideoxynucleosides are both potent antiviral agents. In particular, they are Nucleoside Reverse Transcriptase Inhibitors and hence active against HIV, the ethiological agent of AIDS. They are also intermediates for the synthesis of antiviral 2,3-dideoxynucleosides. Various aspects of synthetic routes to 2,3-unsaturated nucleosides are reviewed with examples being chosen from work published between 1966 and 2003.

Keywords:

reverse transcriptase (RT), Halogenoacetate, bromomesylate, deprotection, Eastwood reaction

Affiliation:

Synthese et Reactivite des Substances Naturelles, CNRS UMR 6514, Faculte des Sciences, 40 avenue du Recteur Pineau, 86022 Poitiers, France.



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