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Recent Developments in Epoxide Preparation

[ Vol. 3 , Issue. 4 ]

Author(s):

G. Sello, Tiziano Fumagalli and F. Orsini   Pages 457 - 476 ( 20 )

Abstract:


This review will present recent achievements in the use of novel reactants and synthetic procedures for the transformation of substrates into epoxide derivatives. This will include both classical chemical methods using novel catalysts and/or cleaner methodologies, and enzymatic preparations using enzymes or cells. Special attention is paid to the preparation of chiral compounds. A comparison of the advantages and disadvantages of the different preparations is also included.

Keywords:

Epoxide synthesis, metals-mediated reactions, ketone-mediated reactions, epoxides from carbonyls, enzymatic reactions, enantioselective preparations

Affiliation:

Dipartimento di Chimica Organica e Industriale, Via Venezian 21 - 20133 Milano - Italy.



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