G. Zappia, E. Gacs-Baitz, G. Delle Monache, D. Misiti, L. Nevola and B. Botta Pages 81 - 135 ( 55 )
The 1,3-oxazolidin-2-one nucleus is a popular heterocycle framework in synthetic organic chemistry, as well as in medicinal chemistry. This paper deals with the huge number of synthetic approaches addressed to the construction of this five-member ring, with a particular care for the mechanistic and stereochemical outcome.
1,3-Oxazolidin-2-one, cyclocarbamation reactions, 1,2-aminoalcohol, epoxides and aziridines, amino-acids, Curtius- rearrangement
Ist. di Chimica Farmaceutica, Università degli Studi di Urbino “Carlo Bo”, P.za del Rinascimento 6, 61029 Urbino Italy.