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Oxazolidin-2-one Ring, a Popular Framework in Synthetic Organic Chemistry: Part 1. The Construction of the Oxazolidin-2-one Ring

[ Vol. 4 , Issue. 1 ]


G. Zappia, E. Gacs-Baitz, G. Delle Monache, D. Misiti, L. Nevola and B. Botta   Pages 81 - 135 ( 55 )


The 1,3-oxazolidin-2-one nucleus is a popular heterocycle framework in synthetic organic chemistry, as well as in medicinal chemistry. This paper deals with the huge number of synthetic approaches addressed to the construction of this five-member ring, with a particular care for the mechanistic and stereochemical outcome.


1,3-Oxazolidin-2-one, cyclocarbamation reactions, 1,2-aminoalcohol, epoxides and aziridines, amino-acids, Curtius- rearrangement


Ist. di Chimica Farmaceutica, Universit√† degli Studi di Urbino “Carlo Bo”, del Rinascimento 6, 61029 Urbino Italy.

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