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Rapid Syntheses of Biologically Active Quinazolinone Natural Products Using Microwave Technology

[ Vol. 4 , Issue. 2 ]


Ji-Feng Liu   Pages 223 - 237 ( 15 )


Quinazolinone alkaloids are a class of natural products possessing a variety of biological activities. In addition, the quinazolinone core scaffold has been extensively utilized as a drug-like template in medicinal chemistry and considered a privileged structure. We have devised a novel, one-pot, highly efficient entry into multiply substituted quinazolinones using microwave technology and applied this methodology to the total syntheses of series of quinazolinone-containing natural products. This review will highlight the total syntheses of these natural products and their analogs under microwave conditions.


Natural Products, Microwave Irradiation, Alantrypinone, quinazolinobenzodiazepine alkaloid, asperlicin E, isaindigotone


Aberjona Laboratories,Inc., 200 Boston Ave., Suite 1250, Medford, MA 02155, USA.

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