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Selected Recent Advances in the Stereoselective Synthesis of Isoquinoline and β-Carboline Derivatives with the Use of Chiral Auxiliaries of Natural Origin

[ Vol. 2 , Issue. 3 ]


Zbigniew Czarnocki, Aleksandra Siwicka and Joanna Szawkalo   Pages 301 - 331 ( 31 )


Various aspects of stereoselective synthesis of tetrahydroisoquinolines and tetrahydro-β-carbolines with the use of natural compounds as chirality sources are reviewed. The following low molecular weight substrates are considered: carbohydrates, isoprenoids, hydroxyacids, alkaloids and amino acids. Examples of various synthetic methodologies that employ the above derivatives as chiral building blocks, chiral auxiliaries or chiral ligands are presented.


stereochemistry, alkaloids, pictet-spengler, bischler-napieralski, enantiomers, diastereomers


Faculty of Chemistry, Warsaw University, Pasteura 1, 02-093, Warszawa, Poland.

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