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Recent Advances in Microwave-Assisted Synthesis of Heterocyclic Compounds

[ Vol. 2 , Issue. 3 ]

Author(s):

Valentina Molteni and David A. Ellis   Pages 333 - 375 ( 43 )

Abstract:


Heterocyclic scaffolds represent the central framework of many biologically active compounds. The goal of this review is to present advances in the field of microwave-assisted synthesis of heterocyclic compounds that have been described in the literature since 1994. In particular, it focuses on reactions in which a heteroatom is directly participating in the bond forming process that gives rise to a heterocyclic core. The review is divided into two sections, cycloaddition and cyclization reactions, which are further classified according to ring type. These reactions are discussed from a synthetic standpoint with emphasis on comparison between microwave and conventional techniques.

Keywords:

microwave technology, acylation, deprotection, cycloaddition, polarization, single-mode reactors, isoxazolidines, indolizines, diels-alder reaction, thiiranes

Affiliation:

Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego,CA 92121, USA.



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