Valentina Molteni and David A. Ellis Pages 333 - 375 ( 43 )
Heterocyclic scaffolds represent the central framework of many biologically active compounds. The goal of this review is to present advances in the field of microwave-assisted synthesis of heterocyclic compounds that have been described in the literature since 1994. In particular, it focuses on reactions in which a heteroatom is directly participating in the bond forming process that gives rise to a heterocyclic core. The review is divided into two sections, cycloaddition and cyclization reactions, which are further classified according to ring type. These reactions are discussed from a synthetic standpoint with emphasis on comparison between microwave and conventional techniques.
microwave technology, acylation, deprotection, cycloaddition, polarization, single-mode reactors, isoxazolidines, indolizines, diels-alder reaction, thiiranes
Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego,CA 92121, USA.