Carmen Avendano and J. Carlos Menendez Pages 65 - 82 ( 18 )
N-Methylwelwitindolinone C isothiocyanate (welwistatin), isolated from the blue-green alga Hapalosiphon welwitschii, is a potent MDR inhibitor. This review deals with synthetic efforts aimed at welwistatin itself or its fragments, together with work concerning the bicyclo[4.3.1]decane and cyclohepta[cd]indole systems, which are related to the CD and ABC fragments of the natural product.
bicyclo decanes, rhodium carbenoids, aryllead triacetates, ring-closing metathesis, multi-drug resistance
Departamento de Quimica Organica y Farmaceutica, Facultad de Farmacia, Universidad Complutense, 28040 Madrid, Spain.