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Syntheses and Biological Activities of Iminosugars as α-L-Fucosidase Inhibitors

[ Vol. 8 , Issue. 1 ]

Author(s):

Elena Moreno-Clavijo, Ana T. Carmona, Antonio J. Moreno-Vargas, Lidia Molina and Inmaculada Robina   Pages 102 - 133 ( 32 )

Abstract:


A review dealing with iminosugars as inhibitors of α-L-fucosidases is presented. The different synthetic approaches for the preparation of the most relevant ones as well as their inhibitory properties are presented.

Keywords:

Azafagomines, hydroxylated azepanes, piperidines, pyrrolidines, fucosidase inhibitors, iminosugars, azasugars, L-Fucosidase Inhibitors, glycosylation, glycosylation reactions, hydrolysis, glycoconjugates, carcinomas, L-fucosidases, Thermotoga maritima, Thermotoga maritima enzyme, iminocyclitols, hydrophobic, POLYHYDROXYLATED PYRROLIDINES, meso-pyrrolidine 1, human placenta, chromatography, Holzapfel, Crous method, Oxime, Bayon's method, pyrrolidinethylphosphonate, nitrone, Cope-House cyclization, tetraacetate, POLYHYDROXYLATED PIPERIDINES, POLYHYDROXYHEXAHYDROPYRIDAZINES, POLYHYDROXYAZEPANES

Affiliation:

Department of Organic Chemistry, Faculty of Chemistry, University of Seville, P.O. Box 1203, E-41071 Seville, Spain.



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