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Direct Propargylic Substitution of Hydroxyl Group in Propargylic Alcohols

[ Vol. 5 , Issue. 1 ]


George W. Kabalka and Min-Liang Yao   Pages 28 - 32 ( 5 )


Nucleophilic substitution reactions involving propargylic alcohols are important because the alkynyl group can be subsequently transformed into a variety of functional groups. This review summarizes recent direct substitution reactions of hydroxyl groups in propargylic alcohols, reactions that are highly desirable due to atom efficiency and environmental concerns.


Ruthenium Catalyzed Substitution, propargylamines, aromatic propargylation, alkoxides, regioselectivity


Departments of Chemistry and Radiology, The University of Tennessee, Knoxville, Tennessee, 37996-1600.

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