Submit Manuscript  

Article Details


Direct Propargylic Substitution of Hydroxyl Group in Propargylic Alcohols

[ Vol. 5 , Issue. 1 ]

Author(s):

George W. Kabalka and Min-Liang Yao   Pages 28 - 32 ( 5 )

Abstract:


Nucleophilic substitution reactions involving propargylic alcohols are important because the alkynyl group can be subsequently transformed into a variety of functional groups. This review summarizes recent direct substitution reactions of hydroxyl groups in propargylic alcohols, reactions that are highly desirable due to atom efficiency and environmental concerns.

Keywords:

Ruthenium Catalyzed Substitution, propargylamines, aromatic propargylation, alkoxides, regioselectivity

Affiliation:

Departments of Chemistry and Radiology, The University of Tennessee, Knoxville, Tennessee, 37996-1600.



Read Full-Text article