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Enzymatic Synthesis of Plant Polyketides

[ Vol. 5 , Issue. 3 ]

Author(s):

Shepo Shi, Hiroyuki Morita, Kiyofumi Wanibuchi, Yuusuke Mizuuchi, Hiroshi Noguchi and Ikuro Abe   Pages 250 - 266 ( 17 )

Abstract:


The functional diversity and catalytic potential of type III polyketide synthases are remarkable. The enzymes catalyze iterative decarboxylative condensations of malonyl unit (Claisen-type C-C bond formation) with a CoA-linked starter molecule to produce structurally diverse, pharmaceutically important secondary metabolites. Recent studies have revealed intimate structural details of the enzyme reactions, which enabled the precursor-directed and structure-based engineered biosynthesis of unnatural polyketides.

Keywords:

Type III polyketide synthase, enzymatic synthesis, precursor-directed biosynthesis, structure-based engineered biosynthesis, combinatorial biosynthesis

Affiliation:

University of Shizuoka, School of Pharmaceutical Sciences, 52-1 Yada, Shizuoka 422-8526, Japan.



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