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C2-Symmetric Pyrrolidines Derived from Tartaric Acids: Versatile Chiral Building Blocks for Total Synthesis, Catalyst Design, Supramolecular and Medicinal Chemistry

[ Vol. 6 , Issue. 1 ]

Author(s):

Andreas Blum and Wibke E. Diederich   Pages 38 - 53 ( 16 )

Abstract:


Chiral 3,4-difunctionalized pyrrolidines, which can be derived from L-(+)- and D-(-)-tartaric acids, are useful and versatile building blocks in total synthesis, catalyst preparation as well as supramolecular and medicinal chemistry. The preparation of these azacycles, possible transformations and their application are described herein.

Keywords:

Tartaric Acids, C2-Symmetric Pyrrolidines, Chiral, Total Synthesis, Catalyst Design, Medicinal Chemistry

Affiliation:

Institut fur Pharmazeutische Chemie, Philipps-Universitat Marburg, D-35032 Marburg, Germany.



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