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Solid-Supported Ammonium Fluorides in Organic Synthesis

[ Vol. 6 , Issue. 2 ]

Author(s):

F. Fringuelli, D. Lanari, F. Pizzo and L. Vaccaro   Pages 203 - 218 ( 16 )

Abstract:


The use of fluoride ion as a base and nucleophile has been widely exploited in organic synthesis. On the other hand over the last few decades the fast-growing development of polymer supported reagents has led to the synthesis of a variety of fluorides on solid support. Such compounds display some major benefits: i.e they are less hygroscopic, easy to recover and to recycle. Tetraalkylammonium fluorides represent some of the most common available sources of fluoride, their solid-supported analogues have been employed in a large range of organic reactions.

Keywords:

Tetraalkylammonium fluoride, solid-supported organo catalyst, polymer-supported fluoride, ion-exchange resin, amberlyst A-26 fluoride form

Affiliation:

Laboratory of Green Synthetic Organic Chemistry, Dipartimento di Chimica, Universita di Perugia, Via Elce di Sotto, 8 I-06123–Perugia Italia.



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