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Biocatalysis in the Preparation of the Statin Side Chain

[ Vol. 6 , Issue. 4 ]

Author(s):

Arto Liljeblad, Annukka Kallinen and Liisa T. Kanerva   Pages 362 - 379 ( 18 )

Abstract:


Statins used in the treatment of dyslipidemias are top-selling drugs in the world. Economical production of statins in industrial scale is challenging, because the side chain of statins is a 3,5-dihydroxyacid derivative consisting of two asymmetric centers. The most prominent methods for the preparation of the side chain are based on biocatalysis and surveyed in this review.

Keywords:

Statin, cardiovascular disease, biocatalysis, dehydrogenase, lipase, haloalcohol dehalogenase, nitrilase, aldolase

Affiliation:

Pharmacology, Drug Development and Therapeutics, Laboratory of Synthetic Drug Chemistry and Department of Chemistry, University of Turku, Lemminkaisenkatu 5 C, FIN-20520, Turku, Finland.



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