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Biocatalysis in the Preparation of the Statin Side Chain

[ Vol. 6 , Issue. 4 ]


Arto Liljeblad, Annukka Kallinen and Liisa T. Kanerva   Pages 362 - 379 ( 18 )


Statins used in the treatment of dyslipidemias are top-selling drugs in the world. Economical production of statins in industrial scale is challenging, because the side chain of statins is a 3,5-dihydroxyacid derivative consisting of two asymmetric centers. The most prominent methods for the preparation of the side chain are based on biocatalysis and surveyed in this review.


Statin, cardiovascular disease, biocatalysis, dehydrogenase, lipase, haloalcohol dehalogenase, nitrilase, aldolase


Pharmacology, Drug Development and Therapeutics, Laboratory of Synthetic Drug Chemistry and Department of Chemistry, University of Turku, Lemminkaisenkatu 5 C, FIN-20520, Turku, Finland.

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