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Synthesis of chroman-4-ones by Reduction of Chromones

[ Vol. 7 , Issue. 3 ]


Volodymyr Semeniuchenko, Ulrich Groth and Volodymyr Khilya   Pages 276 - 309 ( 34 )


The articles which report about the synthesis of chroman-4-ones by hydrogenation/reduction of the corresponding chromones are reviewed. The following methods of synthesis are reviewed: hydrogenation over palladium, platinum, Raney-nickel, catalytic transfer hydrogenation, homogeneous hydrogenation, reduction by complex hydrides, by DIBALH and some special methods. For every appropriate reaction yield, the duration and some additional information is given (if available). Moreover, many exceptions and interesting transformations are described.


Heterocycles, reduction, heterogenous catalysis, homogenous catalysis, hydrogen transfer, flavonoids, chromones, chroman-4-ones


Fachbereich Chemie und Konstanz Research School Chemical Biology der Universitat Konstanz, Fach M-720, Universitatsstrasse 10, 78457 Konstanz, Germany.

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