Adam J.M. Burrell and Iain Coldham Pages 312 - 331 ( 20 )
This review describes ylide 1,3-dipoles in cycloaddition reactions for the synthesis (and formal synthesis) of natural products. Examples using azomethine ylides, carbonyl ylides, nitrones, nitronates, nitrile oxides and azides are provided. These lead to a diverse array of heterocyclic products. Intramolecular cycloaddition provides two new rings in one step and hence an efficient entry to complex target compounds.
Cycloaddition, dipoles, natural products, synthesis, ylides
Department of Chemistry, University of Sheffield, Sheffield S3 7HF, UK.