Submit Manuscript  

Article Details


Synthesis of Natural Products Using Intramolecular Dipolar Cycloaddition Reactions

[ Vol. 7 , Issue. 4 ]

Author(s):

Adam J.M. Burrell and Iain Coldham   Pages 312 - 331 ( 20 )

Abstract:


This review describes ylide 1,3-dipoles in cycloaddition reactions for the synthesis (and formal synthesis) of natural products. Examples using azomethine ylides, carbonyl ylides, nitrones, nitronates, nitrile oxides and azides are provided. These lead to a diverse array of heterocyclic products. Intramolecular cycloaddition provides two new rings in one step and hence an efficient entry to complex target compounds.

Keywords:

Cycloaddition, dipoles, natural products, synthesis, ylides

Affiliation:

Department of Chemistry, University of Sheffield, Sheffield S3 7HF, UK.



Read Full-Text article