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Chiral Lewis Acid Catalysis in Water

[ Vol. 8 , Issue. 3 ]

Author(s):

Chikako Ogawa and Shu Kobayashi   Pages 345 - 355 ( 11 )

Abstract:


The progress of development in chiral Lewis acid catalyzed reaction in water is described. Lewis acid surfactant-combined catalyst and chiral bipyridine ligand complex realized catalytic asymmetric hydroxymethylation and ring-opening reaction in water successfully. Furthermore, silica-supported Lewis acid catalyst was applied for asymmetric hydroxylation in water.

Keywords:

Aldol reaction, Chiral Lewis acid, Epoxide, Green chemistry, Lewis acid, Mannich reaction, Water, asymmetric, organic, solvents

Affiliation:

Department of Chemistry, School of Science and Graduate School of Pharmaceutical Sciences, The University of Tokyo,Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.



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