Submit Manuscript  

Article Details

Chiral Lewis Acid Catalysis in Water

[ Vol. 8 , Issue. 3 ]


Chikako Ogawa and Shu Kobayashi   Pages 345 - 355 ( 11 )


The progress of development in chiral Lewis acid catalyzed reaction in water is described. Lewis acid surfactant-combined catalyst and chiral bipyridine ligand complex realized catalytic asymmetric hydroxymethylation and ring-opening reaction in water successfully. Furthermore, silica-supported Lewis acid catalyst was applied for asymmetric hydroxylation in water.


Aldol reaction, Chiral Lewis acid, Epoxide, Green chemistry, Lewis acid, Mannich reaction, Water, asymmetric, organic, solvents


Department of Chemistry, School of Science and Graduate School of Pharmaceutical Sciences, The University of Tokyo,Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.

Read Full-Text article