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Molecular Imaging Probe Development Using Microfluidics

[ Vol. 8 , Issue. 4 ]

Author(s):

Kan Liu, Ming-Wei Wang, Wei-Yu Lin, Duy Linh Phung, Mark D. Girgis, Anna M. Wu, James S. Tomlinson and Clifton K.-F. Shen   Pages 473 - 487 ( 15 )

Abstract:


In this manuscript, we review the latest advancement of microfluidics in molecular imaging probe development. Due to increasing needs for medical imaging, high demand for many types of molecular imaging probes will have to be met by exploiting novel chemistry/radiochemistry and engineering technologies to improve the production and development of suitable probes. The microfluidicbased probe synthesis is currently attracting a great deal of interest because of their potential to deliver many advantages over conventional systems. Numerous chemical reactions have been successfully performed in micro-reactors and the results convincingly demonstrate with great benefits to aid synthetic procedures, such as purer products, higher yields, shorter reaction times compared to the corresponding batch/macroscale reactions, and more benign reaction conditions. Several ‘proof-of-principle’ examples of molecular imaging probe syntheses using microfluidics, along with basics of device architecture and operation, and their potential limitations are discussed here.

Keywords:

Microfluidics, molecular imaging, Probe Developments, Magnetic Resonance Imaging, Quantum Dots, Ultrasound Imaging, Microfluidic Devices, Imaging Modalities, Fluorescent Tags for Optical Imaging, Positron Emission Tomography

Affiliation:

Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at University of California, Los Angeles, 23-120 Center for Health Science, Los Angeles, California 90095, USA.



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