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Molecular Probes for Bioluminescence Imaging

[ Vol. 8 , Issue. 4 ]


Song Wu, Edwin Chang and Zhen Cheng   Pages 488 - 497 ( 10 )


Bioluminescence refers to the emission of light from a living system in which photoproteins such as luciferase enzymes oxidize their substrates to produce light. Because of its high-sensitivity and low-toxicity, bioluminescence imaging (BLI) is particularly useful for in vitro assays and in vivo small animal imaging. It provides a powerful tool to study various important biological questions and processes including gene and protein expression, protein-protein interactions, protein-nucleic acid interactions, and cell signaling pathway functions. This review highlights some of the latest developments in the design and applications of molecular probes for BLI.


Bioluminescence imaging, Molecular Imaging, Probe, Luciferase, Bioluminescence Resonance Energy Transfer, MRI, Luciferase Mutugenesis, D-luciferin Analogs, Luciferase Fused Proteins, Intramolecular Enzyme Complementation


Molecular Imaging Program at Stanford, Department of Radiology, 1201 Welch Road, Lucas Expansion, P095, Stanford University, Stanford, CA 94305, USA.

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