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Near-Infrared Dyes: Probe Development and Applications in Optical Molecular Imaging

[ Vol. 8 , Issue. 4 ]

Author(s):

Donald D. Nolting, John C. Gore and Wellington Pham   Pages 521 - 534 ( 14 )

Abstract:


The recent emergence of optical imaging has brought forth a unique challenge for chemists: development of new biocompatible dyes that fluoresce in the near-infrared (NIR) region for optimal use in biomedical applications. This review describes the synthesis of NIR dyes and the design of probes capable of noninvasively imaging molecular events in small animal models.

Keywords:

Cyanine, fluorescence, FRET, imaging, optical, probe, rhodamine, near-infrared (NIR) region, near-infrared (NIR) dyes, Fluorescent Dyes, Cyanine Dyes

Affiliation:

Vanderbilt University Institute of Imaging Science, Vanderbilt University, 1161 21st Avenue South, Medical Center North, AA-1105, Nashville, TN 37232-2310, USA.



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