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Recent Progress in Radiofluorination of Peptides for PET Molecular Imaging

[ Vol. 8 , Issue. 4 ]


Shuanglong Liu, Bin Shen, Frederick T. Chin and Zhen Cheng   Pages 584 - 592 ( 9 )


Because of its low positron energy, lack of side emission, and a moderate half-life, Fluorine-18 (β+, 0.635 MeV [97%], t1/2 = 109.8 min) has ideal physical properties for positron emission tomography (PET). With the increasing numbers of peptides that are potentially applicable for molecular imaging of diseases, novel and simple 18F-labeling methods have been actively investigated and reported. In this review, a few well established and widely-used radiofluorination strategies are discussed. Novel approaches including click chemistry, one-step chelation labeling (i.e. Al18F-NOTA), and silicon-based 18F labeling are described as well.


18F, Radiofluorination, Positron emission tomography, Peptide, Molecular Imaging, SPECT, chelation labeling, click reaction, HPLC


Molecular Imaging Program at Stanford, Department of Radiology, 1201 Welch Road, Lucas Expansion, P095, Stanford University, Stanford, CA 94305, USA.

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