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Heterocycle Synthesis Based on Palladium-Catalyzed C-H Bond Functionalization Methods

[ Vol. 9 , Issue. 1 ]


Raffaella Ferraccioli   Pages 96 - 113 ( 18 )


This Review reports recent developments in the synthesis of benzo-fused heterocycles through Pd-catalyzed carbon-carbon and carbon-heteroatom bond forming reactions via direct C-H activation. Nitrogen-, oxygen- and sulfur-containing heterocyclic rings can be rapidly assembled starting from precursors with minimal preactivation. Compared to classical coupling reactions (i.e. Suzuki, Stille, Buchwald-Hartwig), these methods provide a more straightforward and economical route to various heterocyclic scaffolds, which is of practical importance considering their role in biology and pharmaceutical industry.


Palladium, Homogeneous Catalysis, C-H Activation, Organic Halides, Oxidation, Heterocycles, Cyclization, palladium-catalyzed, C-H bond activation/C-C coupling reactions, cross-coupling, regioselectivity, heteroarenes


CNR-Istituto di Scienze e Tecnologie Molecolari (ISTM), Via C. Golgi 19, 20133 Milano, Italy.

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